PICSI-Physiological ICSI

PICSI (Physiological ICSI) for sperm selection

In natural fertilization mature sperm bind to hyaluronan, the main component of the cumulus oophorus matrix; immature sperm do no bind (Sabeur et al, 1997).

A selection method based on sperm-HA binding seems to be useful in reducing the potential genetic complications of ICSI. HA-bound spermatozoa show a 5.4-fold reduction on chromosomal anueploidies after ICSI (Jakab et al, 2005.). This HA-selection method allows the execution of a more ‘‘physiologic’’ ICSI than conventional PVP-ICSI (Jean et al, 2001). Injection of HA-bound spermatozoa (HA-ICSI) improves embryo quality and development (Parmegiani et al, 2010).

Currently, two ready-to-use systems specially designed for sperm-HA binding selection are available:

•SPERM SLOW TM (Origio)

• PICSI ® (Origio)

For sperm with poor binding capability as measured on the HBA slide, significant improvements in Clinical Pregnancy rates result when the PICSI® dish is used to idenitfy the bound sperm for ICSI. For slowing down the movement of the sperm to allow for the selection of the most mature, viable spermatozoa for ICSI is used SPERM SLOW.

Selection of competent sperm gives the following advantages:

•Less Fragmentation (D3)

•Higher Blastocyst Conversion Rate

•Improved Blastocyst Quality

•Lower Miscarriage Rate (Worrilow et al., 2011)

HA-selection method provides:

•Higher : Fertilization Rate & Top Quality Embryos

•Lower : Abnormal Fertilization Rate & Abortion Rate

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